This study brings together several innovative approaches to improving child health in sub-Saharan Africa (SSA), where diarrheal diseases remain a major public health challenge.
It is the first multi-country, double-blinded randomized controlled trial of probiotics conducted in SSA.
It explores a new way of using probiotics in early infancy, including repeated booster doses given alongside routine childhood vaccinations, with follow-up during the first six months of life.
It investigates whether probiotics can strengthen the immune response to rotavirus vaccination in SSA.
It examines the potential role of probiotics in helping to address antimicrobial resistance (AMR) in SSA where the irrational use of antibiotics is rampant.
It applies machine learning methods to develop early warning signals of diarrheal disese.
It brings together expertise from multiple fields, including health, nutrition, water and sanitation, environmental health and climate, to improve understanding and prediction of disease outbreaks.
